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Supplements9 Benefits Of TUDCA: The Bile Acid That Eases ER Stress, Protects The Liver, And Supports The Mitochondria
TUDCA is a hydrophilic bile acid that works as a chemical chaperone, calming the endoplasmic reticulum stress that sits underneath liver disease, insulin resistance, and neurodegeneration. Here are…
SupplementsThe 11+ Benefits of Damiana (Turnera Diffusa or Aphrodisiaca)
Damiana is a shrub native to southern Texas in the United States, Central America, Mexico, South America, and the Caribbean. Maya Indians called this species mis kok ("broom for asthma"). Damiana has…
Prebiotics TrendingResistant Starch: RS1, RS2, RS3, RS4, And RS5 Are Not The Same Prebiotic
Resistant starch escapes small intestinal digestion and reaches the colon where specific bacteria ferment it to butyrate. This post covers all five RS types and their structural differences, Hi-Maize…
Parkinson'sDJ-1/PARK7: How To Revive NRF2 (with 27+ Ways To Increase Protein Deglycase DJ-1)
Protein deglycase DJ-1 (DJ-1), also known as Parkinson disease protein 7 (PARK7) is a master regulator of redox status.In this post, we will discuss how DJ-1 increases dopamine, enhances…
SkinEczema Beyond The Barrier: The Neuroimmune And Neurovascular Drivers Of Atopic Dermatitis
Eczema is not just a broken barrier or an overactive immune system, it is a feedforward loop where cytokines signal directly to skin nerves and the itch-scratch cycle becomes self-sustaining. Here is…
GutGluten is NOT the Problem - it is ATIs
ATIs make up no more than 4% of wheat proteins, but can trigger powerful immune reactions in the gut that can spread to other tissues in the body.ATIs may be prime candidates of severe forms of…
MCASWhy Histamine Produces So Many Symptoms: The Complete Guide To Histamine Intolerance
Histamine is a molecule that most people associate with allergies, but for a growing number of people with chronic illness it is the hidden driver behind dozens of unexplained symptoms across nearly…
AnxietyCoregulation, Nervous System Dysregulation, And PTSD
Post-traumatic stress disorder is fundamentally a disorder of autonomic dysregulation in which the nervous system becomes locked in defensive states and loses access to the circuitry that allows…
SupplementsDr. Nathan Bryan - All About Nitric Oxide In The Body and Chronic Disease
Dr. Nathan Bryan and I discuss a common underlying problem in most chronic illness - dysregulation of nitric oxide.
MCASGut Serotonin And Mast Cell Activation: The Upstream Driver Most MCAS Protocols Miss
Gut serotonin is one of the most underappreciated upstream drivers of mast cell activation. Enterochromaffin cells make roughly 90% of the body's 5-HT, restrained by SCFA tone and Bifidobacterium.…
AnxietyThe Gut-Brain Axis (And Gut Feelings)
Have you ever been told to go with your gut feeling? This article describes why.Changes in the gut microbiota may cause:Mental health issues (such as anxiety, depression, schizophrenia, and stress)…
DrugsLow Dose Naltrexone, TLR4, And The Endorphin Rebound: Three Mechanisms, One Drug, Very Different Doses
Naltrexone operates through three distinct dose-dependent mechanisms that do not overlap. At 1 to 5 mg (LDN), it antagonizes TLR4 on microglia and triggers an endorphin rebound. Below 1 microgram…
Alzheimer'sThe 8+ Benefits Of J147: A Potent Curcumin Derivative (And How To Make T-006)
Unlike the current drugs approved for Alzheimer's Disease, J147 is neither an acetylcholinesterase inhibitor nor a phosphodiesterase inhibitor, yet it enhances cognition with a short-term…
AutoimmunityTuftsin: Our Natural Autoimmune Switch
Balance The Immune System With Tuftsin Tuftsin has powerful ability to balance and regulate the immune system. Tuftsin shifts the immune response from an inflammatory response to an anti-inflammatory…
Sun & LightThe Sun Diet (Food as Sunscreen)
We need the sun for many biological processes.The sun produces ultraviolet (UV) radiation.UV can cause free radicals in skin cells and this is what causes skin cancer, wrinkles, photo-aging, and sun…
MindsetUsing the 20/10 Method to Make Long Term Memories in Minutes
I've been using the 20/10 method to enhance my learning and bring you daily lessons on YouTube.My favorite part of the 20/10 method is that it is completely free! There is no need to take notes…
CancerThe 10+ Benefits Of Java Tea (Orthosiphon stamineus)
In this post, we will discuss the benefits of Java (Orthosiphon stamineusis), my experience with Java, and where to get the best form.
EpigeneticsHDAC Inhibition And Fear Extinction: The Epigenetic Key To Unlocking Traumatic Memory
The reason exposure therapy fails to produce lasting relief in so many people with PTSD is not psychological resistance. It is a failure of consolidation, and the mechanism is epigenetic. HDAC2…