The Benefits Of Synapsin (Intranasal Nicotinamide Riboside)

I've been using synapsin to counteract brain fog and restore NAD+ levels in my brain. 

Synapsin is a compounded pharmaceutical nasal spray being used for increasing neuronal function in neurocognitive disorders.

The Ingredients:

• Nicotinamide Riboside (form of B3)
  • Naturally found in cows milk R
  • Neuroprotective effects (esp. in those w low tryptophan levels) R
  • Increased neuronal NAD+ pools, thus decrease axonal degeneration (esp after TBI or chronic neuroinflammation) and improve glucose utilization R R R
  • Regulation of sirtuin expression, which controls metabolism/longevity R R
  • Improves mitochondrial metabolism R
  • Technical: ↑NAD+, ↑NRK, ↑NAM R
• Methylcobalamin (Vitamin B12)
  • Lowers homocysteine (problem in AD and Vascular Dementia) R
  • Decreases somatic and autonomic symptoms of diabetic neuropathy R R
• Rg3 - 90% Isolated from Panax Ginseng
  • Neuroprotective, reduces neuroinflammation/microglia activation, improves stress R R R
  • Technical: ↓COX2, ↓iNOS, ↓TNF-alpha, ↓IL-1b R

The point of synapsin is to get these benefits into the brain by easily passing the blood-brain barrier with an intransasal spray.

Thus, synapsin may help regulate NAD+ levels in the brain, something that declines with age and most chronic neuroinflammatory diseases.

NAD+ is important for many cellular processes, including sirtuin regulation, mitochondrial function.

Synapsin is also designed to reduce microglial activation (thus reduce brain fog) and lower high brain homocysteine levels (although I am not a carrier for the risk alleles in MTHFR). R R R

According to the label, you can take 1-2 nasal sprays per nostril 3-4x per day.

The time I took synapsin, I messed up the spray and had red medicine running out of my nose.

The next day I did it correctly...and HOLY SYNAPSIN! - this thing is a nootropic for sure:

• Increased focus
• Increased motivation
• Decreased distractibility
• Boosted cognition

Upon continuous usage days succeeding, I had noticed it quenches any brain fog and keeps me hyper-focused.

The only downsides I used were it can be too stimulating in the evenings and keep me up, it made me feel sometimes slightly feverish (especially when combined with other B-vitamins), and lastly sprayed incorrectly gives my throat irritation. 

Synapsin pairs well with my Bright Light Device, but can be too stimulating when used with too much caffeine or nicotine.

Intranasal Spray (1 spray = 0.1 ml)

• Rg3 - 2 mg/ml
• Nicotinamide riboside - 50 mg/ml
• Methylcobalamin - 2 mg/ml

I noticed that with the increased energy, I could not pair it too well with strong stimulants (like coffee or too much chocolate) as I would develop some mild anxiety after. 

Is Synapsin Safe?

There is no known toxicity or side effects from taking ingredients found in sublingual Rg3/Nicotinamide riboside/Methylcobalamin.

Synapsin is available by compounded prescription only.