Spike Protein Persistence And The Glycocalyx

Spike protein is the part of SARS-CoV-2 that first grabs the sugary coating of your blood vessels, and a growing body of evidence suggests fragments of it can linger in tissue and blood long after the infection clears.

In this post, we will discuss what the endothelial glycocalyx is, how spike protein binds it as a co-receptor step alongside ACE2, what glycocalyx shedding markers tell us about COVID severity, the honest debate over spike persistence, and how all of this maps onto my Junction Dysfunction framework for long COVID microvascular symptoms.

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