The 4+ Benefits Of Zhichan Decoction

Zhichan (Zhi-Chan) is a Chinese herbal medicine that has shown to clinically improve the symptoms of patients with Parkinson's Disease, such as gait disturbances, tremor, speech disorder, self-care ability, bimanual movements, and writing disorders. R

Zhichan is composed of: R

• Astragalus (Milkvetch) - warming effect; increases energy and promotes blood circulation and generation R
• Ginseng  - strengthens qi and confers resistance to senility R
• Glossy privet (Ligustrum lucidum)
• Himalayan teasel
• Magnolia
• Swallowwort (Bunge) - nourishes the blood, tonifies the liver, and invigorates qi and blood R
• Szechwan lovage

1. Increases Dopamine Levels

Zhichan can increase dopamine synthesis in the brain by two main mechanisms:

• Increasing Tyrosine Hydroxylase (TH) - creates more dopamine R
• Reducing Monoamine Oxidase B (MAOB) - inhibits dopamine reuptake/breakdown R

Zhichan may also be useful for promoting growth of neural stem cells into dopaminergic neurons. R

2. May Treat Parkinson's Disease

Zhichan protects the brain in Parkinson's Disease (PD). R

For example, in rodent models of Parkinson's Disease (PD) that are injected with the 6-hydroxy-dopamine, a chemical insult to the substantia nigra, Zhichan can normalize dopamine levels by secretion of striatal dopamine and its metabolite homovanillic acid. R

Zhichan can also reduce inflammatory markers (IL-1b and TNF-α) in models of PD. R

3. Has Antioxidant Properties

Zhichan can increase antioxidant levels in the brain. R

It can increase levels of Superoxide Dismutase (SOD), while reducing Malondialdehyde (MDA). R

4. Protects Cells From Death

By regulating signal transduction protein expression (such as p53 and BCL2), Zhichan can inhibit apoptosis (cell death). R

Nothing observable although studies have only been in animal models.

These are the ingredients:

• Astragalus
• Ginseng 
• Glossy privet
• Himalayan teasel
• Magnolia
• Swallowwort
• Szechwan lovage

How To Use Zhichan:

In rodents, the TH gene expression in the substantia nigra began to increase at 10 days after the administration of Zhichan powder and reached a peak at 20 days. R

Simple:

• Increases  BCL2 R
• Increases DA R
• Increases DOPAC R
• Increases HVA R 
• Increases IL-6 R
• Increases SOD R
• Increases TH R
• Reduces Bax R
• Reduces Caspase-3 R
• Reduces Caspase-8 R
• Reduces Cytochrome C R
• Reduces Fas R
• Reduces IL-1b R
• Reduces MAOB R
• Reduces MDA R
• Reduces p53 R
• Reduces TNF-alpha R
• Reduces TNFR1 R

Advanced:

• Zhichan regulates the expression of monoamine oxidase B and tyrosine hydroxylase in the substantia nigra of Parkinson’s disease rats, and facilitate the secretion of striatal dopamine and its metabolite homovanillic acid, resulting in a neuroprotective effect on substantia nigra neurons in Parkinson’s disease rats. R
• Zhichan capsules have a down-regulation on the expression IL-1 β and TNF-α mRNA and an up-regulation on IL-6 and the T, B lymphocytes in PD mouse. R