Internal Vibrations (aka Body Buzzing)
Internal vibrations (internal tremors) are a sensation that are hard to see from the outside and is described by my doctors as a form of anxiety, when it is not and has clear cut mechanisms for it’s pathology.
I’ve written about this extensively in the past on my post called Why Do I Get Body Buzzing And/Or Internal Tremors? and have learned new mechanisms for this entire pathology that I am happy to share with you today.
Essentially (TLDR) it's from:
Adrenergic activation, oxidative stress and psychosomatic reasons
Lack of blood flow and lack of movement
Hypoglycemia and hypoxia
Chronic latent infections
Brain lesions
Structural causes
Further elucidated in that post are ways to counteract each of these (6) points, and I highly recommend that read, as this is an adjunct to that post and compounds on its basics.
Let’s get into the new deets…
What Do Nerves Do?
Essentially nerves send electrical signals through out the nervous system (from brain to muscle, etc), and uses myelin as a saltatory conductive surface. R
Nerves are grouped in what are called the spinal epineurium (the outer most layer), which if we zoom in turns into the perineurium (contains fascicles), and lastly the endoneurium (which is where you see individual nerves and axons). R
The endoneurium consists of an inner sleeve of material called the glycocalyx and a mesh of collagen. R
Nerves are bundled along with blood vessels, which provide essential nutrients and energy to the enclosed, and metabolically demanding, neurons. R
Nerves, Kynurenine, and Covid
When you have TLR activation from sars-cov-2 and/or microsepsis, along with covid’s IDO influence towards Kynurenine (KYN) metabolites like Kynurenic acid (KYNA) and Picolinic acid (PA), then you can get nerve damage. R
Endotoxemia makes this process happen faster and further contributes to Wallerian Degeneration. R
Wallerian Degeneration
When nerves are damaged from a toxin (like spike), this causes something called Wallerian Degeneration. R
There is a similar pathology that can also happen called Wallerian-Like Degeneration, which I lump them together as the fixes for them both are similar.R
So to put this simply, essentially the wallerian degeneration process is a coordinated removal of axon and tissue debris by schwann cells and macrophages. R
So to further elucidate on this, there is a rapid breakdown of the inner body of an axon, which then the axon creates protein repair mechanisms through a process called chromatolysis. R
During chromatolysis, there is breakdown of the myelin, schwann cells, and more of the terminal part of the axon, as this is the start of the patching-up/repair process of that axon. R
At this point the axon is fragmented, there is a lot of junk and debris from the terminal part of the axon, and macrophages (which are signalled from the endoneurium’s signals from 5HT and Histamine) come in to further break down the debris and junk parts of the terminal axon, but during this time, it leaves the axon exposed while the nucleus side of the axon is producing repair proteins through chromatolysis. R
This is a good thing as it’s an adaptive cleanup mechanism and normally this cleanup process is usually followed by regeneration. R
But, if stuck in chronic inflammation (or many of the pathologies we’ve discussed), then the regeneration process (just like wound healing) does not occur. R
This is why people with nerve degeneration will see things like Anti-Myelin Basic Protein antibodies, as they are in the macrophage repair process in wallerian degeneration/regeneration.
Wallerian Degeneration and Tight Junctions
When tight junctions open, due to glycocalyx loss, there are more toxins available to get into the nerve and cause wallerian degeneration. R R
Also, when there is blood loss (as nerves require capillaries/microcapillaries), the nerves become hypoxic, which make it harder for chromatolysis to happen. R R
It takes time for this repair process to happen…
What are the best ways to counteract these mechanisms?
Wallerian regeneration.
Galetcin 3 Inhibition
My favorite way to block Galectin-3 activation is with Modified Citrus Pectin (Pectasol-C). R R
IDO1 Inhibition
IDO inhibitors:
Andrographis (short term) R
Sophora flavescens (and Martine) R
Other Synergies:
Staying away from Resveratrol (as it induces IDO1), would be a smart to avoid. R
There are other mechanisms for the body buzzing/internal vibrations you can read here.