The 5+ Benefits Of KB220, KB220Z, and Neuroadaptagen Amino-Acid Therapy

There are many ways to improve dopamine levels in the brain - dopamine-enhancing diets, hyper-oxygenation, toxic heavy metal detoxification, exercise, meditation, yoga, but most notably, balancing brain neurotransmitters utilizing nutraceuticals aka "neuronutrients". R

KB220z (aka KB220 and formerly known as LG9939, Recomposize, Genotrim) is a "neuronutrient" that acts on optimizing glutamate, dopamine, serotonin, and endorphins in the brain. R

KB220z is a Neuroadaptagen Amino-Acid Therapy (NAAT) complex composed of precursor amino acids and other ingredients that support neurotransmission: R

• Aloe Vera

• Arabinogalactans

• Astragalus

• Chromium Polynicotinate

• DL-Phenylalanine

• Frankincense

• L-Glutamine

• L-Tyrosine

• N-Acetyl-Cysteine (NAC)

• N-Acetyl-Glucosamine (NAG)

• Passion Flower

• Pyroxidal-5-Phosphate (P5P)

• Rhodiola

• Thiamine

• Vitamin B6 (Pyridoxine HCl)

• White Pine Bark

• 5-Hydroxy-Tryptophan (5-HTP)

In clinical studies, KB220z (KB220) has shown to be improve addictions, weight management, dopamine sensitivity and function, focus, concentration, cognition, energy, stress relief, mood, well-being, and vitality. R

1. Regulates Neurotransmitter Levels

Low dopamine/dopamine deficiency (hypodopaminergia) has been associated with many conditions including: R

• Aging, stress, and sadness

• Excessive cravings

• Impaired exercise and decreased physical performance

• Poor relationships and lack of well-being

• Reduced cognition, decision making, energy, and memory

KB220z helps with dopamine deficiency by improving dopamine synthesis and levels in the brain. R R

This may be useful for those with DRD2, COMT, MTHFR, 5-HT2A, and PPARG2 mutations. R R

2. Helps With Overeating And Weight Loss

KB220z can help with compulsive eating and weight loss. R R

For example, in a study with 27 outpatients attending a supervised diet-controlled treatment program, NAAT users had an average weight loss was 26.96 lbs vs. 10.2 lbs in the control group. R

In another 2 year study with 247 patients, the NAAT group compared to the control lost twice as much weight and regained 14.7% of the weight, while the control group regained 41.7%. R

3. Improves Attention, Motivation, And Wellbeing

KB220z may help with attention problems. R R R R R

For example, in a case study KB220z was able to improve Attention Deficit-Hyperactivity Disorder (ADHD) symptoms (such as increased working memory and reducing reaction times) by increasing theta activity and decreasing alpha activity in the brain . R

In another case study, KB220z taken chronically was able to greatly: R

• Enhance sleep

• Improve focus, mood, smell, and vision

• Improve sociability

• Increase calmness, energy, and motivation

Also, in a third case study, KB220z helped a patient coming off anti-depressants feel significantly better (specifically increased energy, a decreased cravings, and a better overall mood). R 

4. Helps With Addiction And Withdrawal

Problems with brain-reward mechanisms are implicated in many conditions:

• Psychiatric disorders (ie substance-use disorders, affective disorders, eating disorders, and obsessive compulsive disorders) R

• Neurodevelopmental disorders (ie schizophrenia, attention-deficit/hyperactivity disorder, autism spectrum disorders, Tourette's syndrome, conduct disorder/oppositional defiant disorder) R

• Genetic syndromes (ie Fragile X syndrome, Prader-Willi syndrome, Williams syndrome, Angelman syndrome, and Rett syndrome) R

By balancing serotonin, glutamate, dopamine, and endorphins in the brain, KB220z can promote a balance across the brain-reward circuitry. R R R

KB220z may help with these addictions/withdrawals:

• Alcohol R

• Amphetamines and Methamphetamines (and other stimulants) R R

• Antidepressants R

• Cannabis R

• Cocaine R

• Heroine (and other opiates like Oxycodone, Naloxone, etc) R R R

• Nicotine R

• Unwanted activities (such as gambling, self-mutilation, sexual addiction, and drug/food abuse) R R R R

In multiple studies, KB220z therapy (IV treatments and/or oral delivery) very effectively helps prevent relapse after addiction treatment. R R R R

This is because dopamine release can decrease the negative feelings and satisfy abnormal cravings for alcohol, cocaine, heroin, nicotine, etc. R

5. Helps With PTSD and Reduces Nightmares

KB220z may help with Post-Traumatic Stress Disorder (PTSD). R

KB220z may also help with sleep and nightmares. R R R

For example, multiple studies have shown KB220z was able to ameliorate long-term, terrifying, and lucid dreams, while increasing happy and joyful dreams. R R R

I've tried SynaptaLean Rx with great results in improving my mood and focus. 

The effects were not instant (such as taking pure Tyrosine) and took over a week to feel the effects.  

I use SynaptaLean Rx since it's significantly cheaper and has the same effects and ingredients. 

SynaptaGenX is the patented version of KB220z (KB220).

KB220z can be taken orally or intravenously. R

Intravenous + oral administration is more effective than oral alone. R

The half-life of amino-acids is approximately four hours so daily dosage requirements of KB220 is in equal divided doses usually morning and night without food. R

In those taking KB220 to reduces nightmares, "after one month’s use of KB220Z, 2 tablets in the morning and 2 tablets in the evening, the frequency of his unpleasant dreams had decreased from nightly to two-three times a week." R

Most of the ingredients in KB220 are Generally Recognised As Safe (GRAS). R

KB220 (and dopamine agonists) may work better for those who are carriers of the DRD2 (Taq1) A1 allele, as they seem to require dopaminergic agonistic intervention. R R

Simple:

• Increases Dopamine R

• Increases GABA R

• Increases Opioids R

• Increases TAAR-1 R

• Increases 5-HT R

• Reduces COMT R

• Reduces Enkephalinase R

• Reduces MAO R

Advanced:

• KB200z increases blood-oxygen-level dependent (BOLD) activation in the caudate-accumbens-dopaminergic pathways and reduces resting state activity in the putamen of abstinent heroin addicts. R

• 5-HTP helps synthesize serotonin in the hypothalamus. R

• Chromium boosts serotonin synthesis (acting on insulin receptors increasing insulin receptor sensitivity), which changes tryptophan metabolism in the liver - increases brain tryptophan by 33%. R R

• L-phenylalanine (precursor to dopamine) increases dopamine at the Ventral–Tegmental Area (VTA) by 20%.

• L-glutamate is converted to GABA at the substania nigra. R

• D-phenylalanine (by inhibiting enkephalinase) prevents the catabolism of methionine-enkephalin (MENTENK) and other endorphins - this enhances the activity of peptidyl opiates in the hypothalamus. R

• NAC (balances the glutaminergic pathway) - increases glutaminergic system at the VTA (balances glutaminergic pathway) to release dopamine at the Nucleus Accumbens (NAc). R

• Pyridoxine is an enzyme catalyst. R

• Rhodiola inhibits Catecholamine–Methyl-Transferase (COMT) - enhancing the release of dopamine into the synapse to combine with the post dopamine D2 receptor; rhodiola also inhibits mitochondrial MAO-A allowing dopamine to be transferred to the vesicles of presynaptic neurons (D1–D9) for higher dopamine quanta release. R R R

• Arabinogalactans, N-acetylglucosamine, Astragalus, Aloe vera, Frankincense resin, White pine bark extract are immune boosters that have anti-cytokine properties (regulates stress hormones). R

• Passion Flower stimulates the benzodiazepine receptor - there is a reduction in anxiety due to stress from detoxification. R

• In rats KB220z triggers the left nucleus accumbens, cingulate gyrus, anterior thalamic nuclei, hippocampus, pre-limbicandinfra-limbic loci. R