Do You Have Systemic And Long-term Inflammation? (SALI)

Do you have CIRS or other chronic issues that do not resolve with the traditional or adjusted treatments?

In this post, we will discuss what is SALI and how this may be a better way to look at similar chronic diseases.

CIRS isn’t technically the best way to address what happens in the body as there are a multitude other diseases/patholgies that have the same biomarkers as CIRS such as:

• Aging

• Neuroinflammation such as Alzheimer’s Disease, Parkinson’s Disease, MS Stroke, TBI, SCI, and Concussions

• Autoimmunity, Immune Polarization

• CFS/ME and FM

• Depression

• Infections such as Dysbiosis, Endotoxemia, Lyme, Viruses

• Metabolic Disorders, Obesity, Liver Disease, Fibrosis

• Mitochondrial Disease

• Pollution-related Diseases

• Redox Problems, Oxidative Stress

• Sickness Behavior

Neither SALI, nor CIRS, are clinical diagnoses (although SIRS is), but I think SALI may help give us a better indication of what is the problem.

I prefer to use the term Systemic And Longterm Inflammation, or SALI (pronounced Sally) for short, to recognize what is happening.

Chronic Inflammatory Response Syndrome (CIRS) indicates that the body is responding to something previous or ongoing, whereas SALI indicates what I believe is truly going on: inflammation that has gone on for a long time and can reach mostly anywhere in the body (see below for FALI vs SALI).

This may be due to a variety of problems: epigenetic switches, infections, chemicals, autoimmunity, haptens, antibodies, lectins, food intolerances, hypoxia, injury, etc…you get the point.

One of my major problems has been with SALI.

I had symptoms of CIRS, but a lot of the areas of my brain and transcription reports showed a different pathology.

I had suffered from mold exposure while growing up, getting dysbiosis in my late teens, and multiple concussions.

SALI can also develop in certain areas of the body causing Focal inflammation (FALI) of the area (autoantibodies to a certain area).

I generally looks at cytokines found in the CIRS/SALI test as well as a fully encompassing toxicology test and an Organic Acids test.

What kind of biomarkers should you look at?

Here are some possible SALI biomarkers:

• ADH

• EPO

• Ferritin

• GFAP

• HMGB1

• HsCRP

• IGF-1

• IFN-g

• IL-1b/4/6/8/9/10/17/22

• KYNA

• Lactate

• Leptin

• LPO

• MMP-2/9

• Myelin Basic Protein

• NFP

• NGF

• Procalcitonin

• SNTF

• S100β

• TGF-b1

• TNF-a

• UCHL1

• VEGF

• VIP

When treating for SALI, diagnostic tools are very important and no branded "protocol" should be followed.

Follow the "whatever is best for the patient/client" protocol.

Usually after biotoxin exposure, people get suppressed immune systems which means they are prone to stealth infection and detoxification issues.

It’s a lengthy process in getting the body better, so I recommend setting up a consult with me, if you’re struggling with SALI.