Natural Cyclooxygenase 2 (COX-2) Inhibitors (with Genetics and Pathways)
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Natural Cyclooxygenase 2 (COX-2) Inhibitors (with Genetics and Pathways)

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COX Basics

Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme that is responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin.

Inhibiting COX has been used by many pharmaceuticals to reduce pain and inflammation.

For example, Nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen, exert their effects through inhibition of COX. R

COX2 Inhibitors

Foods

  • Grapes R

  • Green Tea R

  • Honey R

  • Hops R

  • Horseradish R

  • Huckleberry R

  • Licorice R

  • Mangosteen Juice R

  • Mint R

  • Nasturtium R

  • Nutmeg R

  • Olive Oil R

  • Parsley R

  • Peanuts (high in lectins) R

  • Pineapple R

  • Prebiotics (specifically FOS) R

  • Raspberries R

  • Red Wine R

  • Resistant Starch R

  • Rooibos Tea R

  • Rosemary R

  • Shiitake R

  • Soy (high in phytoestrogens) R

  • Strawberries R

  • Thyme R

  • Tomatoes (avoid if nightshade intolerant) R

  • Turmeric R

  • Vigna (Bambara Groundnut) R

  • Yerba Mate R

    • Hormones

    Lifestyle

    Pathways

    Supplements

    In the JD Guide

    Chapter 1

    The Glycocalyx: The Root of It All

    The glycocalyx is a microscopic gel layer coating every blood vessel in your body. When it breaks down, blood flow is impaired at the capillary level, the root mechanism behind Long COVID, POTS, MCAS, brain fog, and dozens of conditions conventional medicine treats as unrelated.

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  • Apigenin R

  • Artichoke Extract R

  • Astaxanthin R

  • Astragalus R

  • Bacopa R

  • Beetroot Powder R

  • Berberine R

  • Bitter Melon R

  • Black Catechu R

  • Black Cohosh R

  • Black Seed R

  • Boswellia R

  • Bromelain R

  • Butyrate R

  • Caffeine R

  • Capsicum (contrains Capsaicin) R

  • Carnosol R

  • Cat's Claw R

  • Celery Seed R

  • Chaga R

  • Chamomile Extract R

  • Chinese Sage (Danshen) R

  • Chinese Skullcap (Baicalin) R R

  • Chinese Yew R

  • Chrysin (Passion Flower) R

  • CoQ10 R

  • Cordyceps R

  • Curcumin R

  • Daidzein R

  • Devil's Claw R

  • DHA/EPA R

  • Dogwood Fruit R

  • EGCG R

  • Echinacea R

  • Emodin (Rumex) R

  • Epimedium (Horny Goat Weed/Icariin) R

  • Figwort R

  • Genistein R

  • Ginkgo Biloba R

  • Glossy Privet R

  • Glucosamine R

  • Glutathione R

  • Grape Seed Extract R

  • Gynostemma R

  • Hesperedin R

  • Honokiol (Magnolia) R

  • Hops R

  • Horseradish Extract R

  • Jasmine R

  • Ketones R

  • Licorice R

  • Lion's Mane P R

  • Luteolin R

  • Lycopene R

  • Magnesium R

  • Maitake Mushroom R

  • Milk Thistle P R

  • Moringa P R

  • N-Acetyl-Cysteine R

  • Narigenin R

  • Nettle R

  • Nicotine (Anatabine) R

  • Olive Leaf (Hydroxytyrosol) R

  • Panax Ginseng (Korean) R

  • Perilla R

  • Pterostilbene R

  • PQQ R

  • Pycnogenol R

  • Quercetin R

  • Rehmannia R

  • Reishi R

  • Resveratrol R

  • Rhodiola Rosea R

  • Rosmarinic Acid R

  • Selenium R

  • Shiitake R

  • Sodium Benzoate (found in carbonated drinks, vinegar, fruit juices, pickles, etc) R

  • Spirulina R

  • Sulforaphane R

  • St. Johns Wort (Hyperforin) R R

  • Taxifolin R

  • Theanine R

  • Thunder God Vine R

  • Tulsi (Holy Basil) R

  • Ursolic Acid R

  • Valerian R

  • Vitamin B1 R

  • Vitex R

  • White Willow R

  • Wormwood R

  • Zinc R

    • Drugs:

    Genetics

    COX2/PTGS2

    rs20417 (I'm CC)

    • C Allele

      • 30% higher risk of diabetes (Pima Indian population) R

      • Lower risk of end-stage Osteoarthritis R

      • Higher risk of stroke (African American population) R

      • Lower risk of Myocardial Infarction and stroke (Italian population) R

    • G Alleles

      • Greater risk of end-stage Osteoarthritis R

      • Higher benefit from NSAIDs for disease prevention R

    rs5275 (I'm AG)

    • AA Allele

      • may do better with NSAIDs R

      • higher levels of COX-2 R

    JG

    Jacob Gordon

    INHC, FMT-C

    Board Certified Health Coach

    I spent years battling unexplained chronic illness before discovering biohacking, epigenetics, and functional medicine. Now I share that research at MyBioHack to help others find their own answers.

    Book a Consultation

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