Junction Dysfunction: The Complete Framework

First Edition - the complete original 47-part Junction Dysfunction web guide, reorganized into 42 numbered book chapters across seven parts with linked references, front matter, glossary, and afterword.

This First Edition presents the complete Junction Dysfunction (JD) framework, the mechanism I've spent years developing to examine possible connections among long COVID, POTS, CIRS, ME/CFS, mold illness, and other chronic post-viral conditions. It centers on a compromised glycocalyx and two sub-pathologies I call Transient Capillary Leak Syndrome (TCLS) and Micro-Sepsis (MSS).

Structured as a real book rather than a stitched-together web archive, it walks through the vascular foundations, the immune cascade, gut and cellular terrain, inflammation and wound healing, and the specific mechanisms behind long-hauler symptoms like low cortisol and post-exertional malaise, then closes with the genetics that make some people more susceptible than others.

This is the mechanism, in full. Pair it with the Creating Functional Junctions Action Workbook when you want the original action steps organized into worksheets, safety tiers, and trackers. Applying the framework to your own labs and symptoms over time is what Health Hub, the Biohacking Bot, and Path/Pro membership are built for, and this book includes a discount code to get started there.