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Flipped Circadian Rhythm

Do longhaulers have lower cortisol levels?

They generally don’t, but the testing they are doing for them with their doctors and at labs are during the day time.

This is a problem because their levels of cortisol are higher at night - they have a flipped circadian rhythm.

This makes them tired during the day, but wired/tired at night.

This is why I like to look at multi-snapshot cortisol testing, testing upon awakening, in the morning, as that gives me a trend on what their cortisol levels look like.

Glucocorticoid Receptors

Ok there are people who do have low cortisol levels, and this is a result of inflammation causing Chrousos Syndrome aka glucocoritocoid resistance (GCR) on the hypothalamus. R

Tumor Necrosis Factor-alpha (TNFα) is a pro-inflammatory signaling to induce an acute form GCR. R

This process can actually make you feel depressed (see my video below).

TNFα has a significant and broad impact on the transcriptional performance of glucocorticoid receptor (GR). R

This increases the level of glucocorticoid-induced TNF receptor- related protein (GITR). R

GITR is expressed on activated T cells and constitutively on Tregs, thus able to activate and regulating effects on T-cells. R R

Long term upregulation of GITR has also shown to be a significant driver of atherosclerosis. R R

Regulating Cortisol

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Thanks for reading!