Glycome Atlas
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Glycome Atlas
Atlas pathway
Glycation is a non-enzymatic reaction between reducing sugars or reactive carbonyls and biomolecules; glycosylation is an enzyme-directed cellular process that builds defined glycoconjugates. The similar names describe fundamentally different chemistry.12
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Glycation proceeds without an enzyme directing the site or final structure of the modification.1
Glycosylation uses enzyme systems and activated sugar donors to create regulated glycoconjugates.2
Because the mechanisms differ, a finding about glycation should not be generalized to glycosylation, or vice versa.12
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References