Research Library

Why The Heart Almost Never Gets Cancer: Mechanical Load, Nesprin-2, And The Epigenetics Of A Beating Organ

The heart is one of the only organs that almost never develops cancer, and a 2025 Science paper traces the protection to mechanical load that drives Nesprin-2 signaling, histone methylation, and…

PMDD: The Neurobiology Behind Premenstrual Dysphoric Disorder And How To Address It

Premenstrual dysphoric disorder (PMDD) is a severe cyclic mood disorder with a distinct neurobiological basis involving allopregnanolone, GABA receptor sensitivity, serotonin, and a frequently…

Review of "Reliable" Sources (Updated to 2020)

Gathered Reviews of Suppliers and SourcesDisclaimer: Most of this data is sourced from personal experience, Facebook, or Reddit forums. Be wise and don't buy from some "rando".

Semax: How The Nootropic Peptide Works, Its Legal Gray Zone, And Natural Ways To Raise BDNF

Semax is approved in Russia and essentially unstudied in the West, which is the fact most nootropic writing skips. Here is what the ACTH(4-10) analog actually does at the melanocortin receptors, why…

Keeping Muscle On GLP-1 Drugs: Semaglutide, Tirzepatide, And Retatrutide

GLP-1 drugs like semaglutide, tirzepatide, and retatrutide strip fat fast, but roughly a quarter to a third of the weight lost is lean mass, the part you cannot afford to lose. Here is what the trial…

Coregulation, Nervous System Dysregulation, And PTSD

Post-traumatic stress disorder is fundamentally a disorder of autonomic dysregulation in which the nervous system becomes locked in defensive states and loses access to the circuitry that allows…

Irisin Podcast (Preview)

Amylin's Role in Obesity and Alzheimer's

Amylin is a hormone that is co-stored and co-secreted with insulin from the pancreatic beta cells in response to nutrients (eating). It mediates important brain functions, including appetite…

Tests (groups)

Links to tests and where to get them.

ATG16L1

The ATG16L1 gene provides instructions for making a protein called autophagy related 16-like 1. This protein is part of a larger family of proteins that are required for a process called autophagy.…

Iodine And Thyroid Health: Benefits, Safety, Breast Tissue, And Genetics

Iodine is the one nutrient where too little and too much cause the same disease, and the high-dose protocol culture keeps ignoring that. Here is how the sodium-iodide symporter and TPO actually build…

Phase II Detoxification: Non-Conjugation Reactions (Quinone Reductase and Epoxide Hydrolase)

Phase II detoxification includes a parallel set of non-conjugation reactions that directly modify reactive intermediates produced by Phase I. Quinone reductase (NQO1) and epoxide hydrolase…

The 10+ Benefits Of Oak Wood (Robuvit and Quercus Species)

Robuvit and Oak Wood extracts from the Quercus species have shown to have very promising results in combating fatigue in human trials.In the post, we will discuss the benefits of Quercus species and…

Understanding Blue Light (Blue Light Part 1)

How are you reading this article? On your computer? On your phone? Are you inside? If you answered ‘yes’ to at least one of those questions, chances are, you’re looking at a blue…

The Amazing Benefits of Noopept

Noopept is a performance enhancing peptide for the brain that enhances the sound and flow of music, concentration, and motivation. It isn't a recreational drug and it is 100% legal to buy and…

Acne And Intestinal Permeability: How A Leaky Gut Barrier Drives Breakouts Through Zonulin And Bacterial Fragments

Acne tracks with elevated blood zonulin and a leaky gut barrier that lets bacterial fragments and food antigens drive systemic immune activation. Here is the mechanism, why your trigger food (legumes…

The 17+ Benefits Of Human Immunoglobulin Therapy

Immunoglobulin therapy has many benefits in treating post-infectious diseases and autoimmunity, but careful consideration but be taken into account before therapy.In this post, we will discuss the…

Methylation: Why This One Pathway Controls Almost Everything

Methylation is the most interconnected metabolic pathway in the body, and when it fails, the downstream damage touches neurotransmitters, detoxification, immune regulation, DNA repair, histamine…