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DetoxPhase II Detoxification: Non-Conjugation Reactions (Quinone Reductase and Epoxide Hydrolase)
Phase II detoxification includes a parallel set of non-conjugation reactions that directly modify reactive intermediates produced by Phase I. Quinone reductase (NQO1) and epoxide hydrolase…
Alzheimer'sAre You ApoE4? 88+ Ways To Increase Apolipoprotein E (ApoE)
ApoE is a master regulator for many genes implicated in cholesterol metabolism (such as Alzheimer's Disease and Atherosclerosis).In this post, we will discuss the benefits and downsides of ApoE, how…
SupplementsThe 7+ Benefits of KIOM-79 (with Alternatives)
KIOM-79 is a potent AGE-abolisher and may improve eysight.In this post, we will discuss the benefits of KIOM-79 and an alternative way to source its ingredients.
Parkinson'sCDNF: What It Is and How To Increase Cerebral Dopamine Neurotrophic Factor
Cerebral Dopamine Neurotropic Factor (CDNF) is a newly discovered (and very powerful) way to regrow damaged dopaminergic neurons. It has shown have anti-inflammatory effects that are very beneficial…
DetoxHow Cadmium Damages Mitochondria And What To Do About It
In western society, cadmium (Cd) is found in our everyday environment.It causes toxic effects to the whole body, including the cells and mitochondria.In this post, we will discuss how cadmium affects…
Biliary & Liver10+ Reasons Why Alcohol Intolerance Happens And How To Build Alcohol Tolerance (Mechanisms And Genetics)
Are you someone who could handle their alcohol until getting sick, then any sort of alcohol in any amount may make you sick?This is a common problem with those after their immune system has gone…
SupplementsThe 11+ Benefits of Damiana (Turnera Diffusa or Aphrodisiaca)
Damiana is a shrub native to southern Texas in the United States, Central America, Mexico, South America, and the Caribbean. Maya Indians called this species mis kok ("broom for asthma"). Damiana has…
SupplementsGeoff Palmer: Regulate Testosterone, DHT, Estrogen, Stress, and Fat Naturally with Clean Machine
In this podcast, we will be discussing how to regulate hormones naturally.
MitochondriaHow Chronic Fluoride Can Damage Mitochondria And The Gut Biome
Fluoride is a trace element, but it is found in our daily exposure more than a "trace". In small amounts, it appears to be okay. The problems with fluoride appear to be in chronic use of it over long…
BrainCraniocervical Instability: Causes, Symptoms, Mechanisms, Testing, and How To Improve It
Craniocervical Instability (CCI) is a structural condition in which the ligaments connecting the skull to the upper cervical spine lose their ability to hold the junction stable, allowing excessive…
DietSIBO (Small Intestinal Bacterial Overgrowth): Root Causes, Testing, And Evidence-Based Treatment
SIBO is a downstream signpost, not a primary infection, and antibiotics alone rarely fix it. This post covers the three gas subtypes, the root causes behind the migrating motor complex failure, and…
GutIMO (Intestinal Methanogen Overgrowth): Why Methane Is Not SIBO, And Why It Needs A Different Protocol
Intestinal methanogen overgrowth is driven by archaea, not bacteria, and they colonize the colon as well as the small bowel, so the SIBO label and the small-bowel antibiotic that follows it both…
SupplementsThe 5+ Benefits of KIOM-MA And KIOM-MA128 (with Alternatives)
In this post, we will discuss KIOM-MA as a treatment for many inflammatory diseases.
GeneticsCOMT Genetics, Catecholamine Metabolism, And Attachment Style
COMT sets how fast your body clears dopamine, adrenaline, and catechol estrogens, and the Val158Met variant tunes stress reactivity, fear inhibition, and the catecholamine backdrop that attachment…
AutoimmunityAnti-Mitochondrial Antibodies (AMA-M2): What They Mean Beyond Primary Biliary Cholangitis
Anti-mitochondrial antibodies M2 (AMA-M2) are classically linked to primary biliary cholangitis, but they also appear in autoimmune hepatitis, stroke, lymphoma, and other conditions, and their…
Growth factorsInhibiting Nogo-A For Increased Brain Plasticity
Nogo-A is one of the most potent growth inhibitors in the central nervous system.It is involved in creating new blood cells, developing new stem cells, protecting growth of cancer, and modulating the…
CancerNear-Death Experiences And Ego Death: Psilocybin, Cancer Patients, The Dying Brain, And Safe Ways To Touch The State
Near-death experiences often produce ego death, a temporary collapse of the ordinary self-model where the boundary between "me" and the world becomes less solid. This post reframes NDEs through ego…
SupplementsNatural Cyclooxygenase 2 (COX-2) Inhibitors (with Genetics and Pathways)
Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme that is responsible for formation of prostanoids, including thromboxane and prostaglandins such as…